What changed
In a maintenance study, weekly subcutaneous VK2735 at 17.5 mg produced 22% placebo-adjusted weight loss at Week 33, with no plateau observed. Up to 97% of weight loss was maintained after transitioning to every-other-week dosing for three months, and up to 90% was maintained with monthly dosing. GI adverse event rates during maintenance were similar to placebo. The company plans an oral maintenance dosing part 2 study.
Why it matters
In a maintenance study, weekly subcutaneous VK2735 at 17.5 mg produced 22% placebo-adjusted weight loss at Week 33, with no plateau observed. Up to 97% of weight loss was maintained after transitionin